Congrats to Will and Noah for recent acceptance of their paper “Strain-induced collagen denaturation is rate dependent in failure of cerebral arteries” at Acta Biomaterialia! This research shows that the extent of collagen molecule damage decreases with strain rate when vessels are stretched to failure. Collaborators include Matt Converse and Michael Yu....
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A new proposal entitled “Tissue Damage Progression in Repeated Mild Traumatic Brain Injury” has been funded by the NSF. The new project, including Brittany Coats of the Utah Head Trauma Lab and Michele Marino of the University of Rome, Tor Vergata, will characterize damage to pia-arachnoid complex tissues resulting from repeated loading and study the influence...
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The lab has received notice of new funding from the National Science Foundation. The goals of this project are to define rate-dependent, multiscale damage mechanisms in blood vessels and to link these mechanisms to changes in vessel properties through a constitutive damage model....
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Congratulations to Matt for successfully defending his PhD dissertation entitled “Trauma-Induced Alterations of Cerebral Vessel Mechanics and Microstructure.”...
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Congratulations to Matt and co-authors for acceptance of our paper entitled “Detection and characterization of molecular-level collagen damage in overstretched cerebral arteries” for publication in Acta Biomaterialia! This paper reports the first identification and quantification of collagen damage in blood vessels following overstretch using the novel collagen hybridizing peptide (CHP) invented by the Michael Yu laboratory...
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Congrats to Matt for taking first place in the student paper competition at SB3C in Tucson on June 24! The title of his presentation was “Arterial damage model based on empirical stretch thresholds of collagen unfolding and tissue yielding.” This work utilizes data on collagen fiber unfolding in overstretched vessels to inform a theoretical...
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Congratulations to Will for being selected for participation in the Undergraduate Research Opportunities Program for the Fall 2016 semester! As part of this research, he will investigate cerebral vessel wall collagen fiber damage in traumatic brain injury....
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Congratulations to Matt, Justin, and Ray for presentation of their work at the SB3C Conference in National Harbor, MD, on 6/30/2016. The talk reporting their work was entitled “Direction-Dependent Collagen Disruption in Overstretched Cerebral Arteries” and reports further quantification of collagen damage resulting from circumferential overstretch. Findings were based on the use of collagen...
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