Congrats to Will and Noah for recent acceptance of their paper “Strain-induced collagen denaturation is rate dependent in failure of cerebral arteries” at Acta Biomaterialia! This research shows that the extent of collagen molecule damage decreases with strain rate when vessels are stretched to failure. Collaborators include Matt Converse and Michael Yu....
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Soon-to-be Dr. Noah Pearson successfully defended his dissertation, titled “High Strain Rate Damage in Cerebral Arteries: A Molecular and Mechanical Analysis”!...
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A new proposal entitled “Tissue Damage Progression in Repeated Mild Traumatic Brain Injury” has been funded by the NSF. The new project, including Brittany Coats of the Utah Head Trauma Lab and Michele Marino of the University of Rome, Tor Vergata, will characterize damage to pia-arachnoid complex tissues resulting from repeated loading and study the influence...
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Congratulations to Matt and Kevin for getting their paper entitled “Stretch-induced intimal failure in isolated cerebral arteries as a function of development” published in Annals of Biomedical Engineering! This paper shows that the intimal layer of cerebral arteries commonly ruptures prior to external layers and may have significant implications for vessel dysfunction following traumatic brain...
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Congratulations to Matt for getting his paper entitled “Biaxial softening of isolated cerebral arteries following axial overstretch” accepted for publication at the Journal of the Mechanical Behavior of Biomedical Materials. This paper quantifies changes in circumferential properties following overstretch. See the publications page for more details....
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The lab has received notice of new funding from the National Science Foundation. The goals of this project are to define rate-dependent, multiscale damage mechanisms in blood vessels and to link these mechanisms to changes in vessel properties through a constitutive damage model....
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Our review article entitled “Cerebral blood vessel damage in traumatic brain injury” has been accepted for publication in Clinical Biomechanics. This paper outlines the current state of knowledge on vascular damage in traumatic brain injury....
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Congratulations to Matt for successfully defending his PhD dissertation entitled “Trauma-Induced Alterations of Cerebral Vessel Mechanics and Microstructure.”...
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Congratulations to Matt and co-authors for acceptance of our paper entitled “Detection and characterization of molecular-level collagen damage in overstretched cerebral arteries” for publication in Acta Biomaterialia! This paper reports the first identification and quantification of collagen damage in blood vessels following overstretch using the novel collagen hybridizing peptide (CHP) invented by the Michael Yu laboratory...
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Congrats to Matt for taking first place in the student paper competition at SB3C in Tucson on June 24! The title of his presentation was “Arterial damage model based on empirical stretch thresholds of collagen unfolding and tissue yielding.” This work utilizes data on collagen fiber unfolding in overstretched vessels to inform a theoretical...
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